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KMID : 0861020070220010089
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Korea Journal of Herbology
2007 Volume.22 No. 1 p.89 ~ p.94
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Ethanol extract of Bojungbangam-tang (EBJT) prevents Cisplatin-induced Apoptosis in mice
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Park Sung-Joo
Song Ho-Joon
Jeon Byung-Hoon
Kim Sung-Hoon
Ahn Kyoo-Suk
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Abstract
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Objectives : The purpose of this study is to investigate cisplatin-induced apoptosis by ethanol extract of bojungbangam-tang (EBJT).
Methods : To evaluate of anti-apoptic effects of EBJT, we examined several kinds of cell populations such as CD4{+} T cells, CD8^{+} T cells and macrophages in spleen.
Result : 1. EBJT inhibited cisplatin-induced cell death in spleen. 2. EBJT inhibited the death of CD4{+} and CD8{+} T cells. 3. EBJT slightly recovered the number of macrophages by cisplatin. Furthermore, cisplatin-induced upregulation of class II were inhibited by EBJT.
Conclusion : EBJT prevented cisplatin-induced cell death, which could provide a clinical basic for side effects of anti-tumor therapeutics.
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KEYWORD
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Acanthopanax sessiliflorus, immuno-stimulating, anti-Cancer
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